SLU-PP-322 10mg Research Peptide
SLU-PP-322 is a synthetic small molecule developed at Saint Louis University as the first pan-agonist of all three estrogen-related receptors (ERRα, ERRβ, ERRγ). It does not bind estrogen receptors — the ERRs are orphan nuclear receptors that regulate mitochondrial energy metabolism.
Purity
99.3% HPLC-tested purity with COA support.
Size
10mg Lyophilized Powder.
Storage
-20°C (Freezer)
Research use
For laboratory research use only. Not for human or veterinary use.
Mechanism of action
ERR activation upregulates genes governing oxidative phosphorylation, fatty acid oxidation, mitochondrial biogenesis and slow-twitch muscle fiber identity. In mouse models, SLU-PP-322 increased running endurance by ~70% and reduced body fat without changes in food intake or activity.
Research applications
- Exercise mimetic research
- Obesity and metabolic syndrome studies
- Mitochondrial biogenesis research
- ERR nuclear receptor pharmacology
- Endurance capacity studies
Frequently asked questions
Is SLU-PP-322 a peptide?
No. It's a small-molecule pan-agonist of the ERR family of nuclear receptors. It is grouped with research peptides because it targets the same metabolic pathways as MOTS-C and AICAR.
How does SLU-PP-322 compare to AICAR or MOTS-C?
All three are studied as exercise mimetics but at different nodes: AICAR activates AMPK, MOTS-C is a mitochondrial-derived AMPK modulator, and SLU-PP-322 acts upstream by switching on ERR-driven mitochondrial gene programs.
Does SLU-PP-322 bind estrogen receptors?
No. Despite the name, the estrogen-related receptors (ERRs) are a distinct family of orphan nuclear receptors and SLU-PP-322 does not activate ERα or ERβ.
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