AICAR 50mg Research Peptide
AICAR (5-Aminoimidazole-4-carboxamide ribonucleotide), also called Acadesine, is a cell-permeable nucleoside that converts intracellularly to ZMP, a direct AMP-mimic. It is one of the original tool compounds used to study AMPK pharmacology.
Purity
99.4% HPLC-tested purity with COA support.
Size
50mg Lyophilized Powder.
Storage
-20°C (Freezer)
Research use
For laboratory research use only. Not for human or veterinary use.
Mechanism of action
Once inside the cell, AICAR is phosphorylated to ZMP, which allosterically activates AMPK without altering the AMP/ATP ratio. AMPK activation increases glucose uptake, fatty acid oxidation, mitochondrial biogenesis and PGC-1α expression — earning AICAR the 'exercise in a pill' label in the 2008 Salk Institute paper.
Research applications
- AMPK pathway research
- Endurance and exercise mimetic studies
- Glucose uptake and Type 2 diabetes research
- Ischemia-reperfusion injury studies
- Mitochondrial biogenesis research
Frequently asked questions
Is AICAR a peptide?
No. AICAR is a small-molecule nucleoside analog, not a peptide. It is grouped with peptide research because it targets the same AMPK pathways as MOTS-C, metformin and exercise.
What's the difference between AICAR and metformin?
Both activate AMPK but via different mechanisms. AICAR is a direct AMP-mimic. Metformin acts indirectly by inhibiting mitochondrial complex I. AICAR is more potent in vitro but has a much shorter half-life in vivo.
What purity is your AICAR?
≥99.4% HPLC purity with COA included on every batch.
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