MOTS-C 10mg Research Peptide
MOTS-C (Mitochondrial ORF of the 12S rRNA-c) is a short peptide encoded within mitochondrial DNA. Discovered in 2015 by Pinchas Cohen's lab at USC, it acts as a mitochondrial signaling peptide that crosses into the nucleus during metabolic stress.
Purity
99.4% HPLC-tested purity with COA support.
Size
10mg Lyophilized Powder.
Storage
-20°C (Freezer)
Research use
For laboratory research use only. Not for human or veterinary use.
Mechanism of action
MOTS-C activates AMPK in skeletal muscle and adipose tissue, mimicking many effects of exercise and caloric restriction. It enhances glucose uptake, fatty acid oxidation and mitochondrial biogenesis. Plasma levels decline with age, which has driven interest in it as a geroprotector.
Research applications
- Insulin sensitivity and Type 2 diabetes research
- Exercise mimetic and metabolic studies
- Mitochondrial biogenesis research
- Longevity and aging research
- AMPK pathway pharmacology
Frequently asked questions
Why is MOTS-C called an exercise mimetic?
MOTS-C activates AMPK and increases mitochondrial biogenesis — the same molecular pathways triggered by aerobic exercise. Preclinical models show similar improvements in glucose disposal and endurance.
Is MOTS-C 10mg or 40mg better for research?
The 10mg vial is the standard research size. The 40mg vial is bulk pricing for longer protocols — same compound, same purity, lower cost per mg.
What does the COA cover?
≥99.4% HPLC purity, mass-spec sequence confirmation, endotoxin testing and lot-specific batch number.
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