Buy MOTS-C 10mg, 40mg
MOTS-C is a mitochondrial-derived peptide supplied by Amino Fuel Labs for controlled laboratory research involving insulin sensitivity and type 2 diabetes research, exercise mimetic and metabolic studies, mitochondrial biogenesis research. It is available as 10mg, 40mg in lyophilized powder. Each lot is released against third-party reversed-phase HPLC testing reporting 99.4% purity, with the batch-specific Certificate of Analysis linked on this page. For laboratory research only.
- 99.4% purity (reversed-phase HPLC)
- Third-party lab tested with batch-matched COA
- Same-day US dispatch before 2:00 PM ET · free over $300
- Secure checkout
Research Use Only. This product is intended strictly for laboratory research purposes. It is not intended for consumption, diagnosis, treatment, prevention or clinical application.
MOTS-C sizes, pricing and cost per mg
| Size | Price | Cost per mg | Availability | Certificate |
|---|---|---|---|---|
| 10mg | $60.00 | $6.00 / mg | In stock | 10mg COA |
| 40mg | $140.00 | $3.50 / mg | In stock | 40mg COA |
- 99.4% purity reported by reversed-phase HPLC.
- Lot-matched Certificate of Analysis: view the MOTS-C COA.
- Same-day USA dispatch on orders placed before 2:00 PM ET.
- Free shipping on orders over $300.
For laboratory research use only.
MOTS-C COA and lot verification
Each MOTS-C lot ships with a third-party Certificate of Analysis that lists the lot identifier, the reversed-phase HPLC purity result and the mass-spectrometry identity confirmation for that batch. Match the lot number printed on the vial to the lot on the COA before the material is used in any in-vitro protocol; if the two do not match, contact us for the correct document.
- MOTS-C Certificate of Analysis
- All third-party lab reports
- How our quality testing works
- How to read a Certificate of Analysis
Related research reading
What is MOTS-C?
MOTS-C (Mitochondrial ORF of the 12S rRNA-c) is a short peptide encoded within mitochondrial DNA. Discovered in 2015 by Pinchas Cohen's lab at USC, it acts as a mitochondrial signaling peptide that crosses into the nucleus during metabolic stress.
Explore MOTS-C research peptide options for laboratory work, including MOTS-C 10mg and other currently available vial sizes. Compare the selected variant's specifications and associated documentation before choosing material. For readers following mitochondrial peptide research, our linked research article provides context for evaluating published studies. For laboratory research only.
How MOTS-C works
MOTS-c is a 16-amino-acid mitochondrial-derived peptide encoded by the 12S rRNA locus; it activates AMPK through the folate–purine pathway, targets skeletal muscle, and translocates to the nucleus to regulate adaptive gene expression under metabolic stress. In the original preclinical report (Lee et al., Cell Metabolism, 2015), MOTS-c treatment prevented age- and high-fat-diet-induced insulin resistance in mice — an animal finding, not a human outcome. This mechanistic profile is why MOTS-c is one of the most-requested research compounds in the mitochondrial-derived peptide category, and why purity verification matters so much — even small impurity differences can alter receptor-binding data in published in-vitro work.
Why researchers buy MOTS-C from Amino Fuel Labs
- 99.4% HPLC purity — independently verified per batch by an independent third-party lab.
- Mass-spectrometry identity confirmation included on every Certificate of Analysis.
- Same-day USA dispatch on orders placed before 2:00 PM ET.
- Free shipping on every order over $300.
- No-fee replacement on any vial that arrives damaged or off-spec.
MOTS-C technical specifications
Classification
Mitochondrial-Derived Peptide
Research area
Mitochondrial-Derived Peptide
CAS number
1627580-64-7
Synonyms
Mitochondrial ORF of the 12S rRNA type-c
Molecular formula
C₁₀₁H₁₅₂N₂₈O₂₂S₂
Molecular weight
2174.62 g/mol
Amino acid count
16 residues
Sequence
MRWQEMGYIFYPRKLR (Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg)
Physical form
Lyophilized Powder (10mg)
Purity
99.4%
Solubility
Soluble in bacteriostatic water; consult the lot-matched COA for solvent recommendations.
Storage
-20°C (Freezer)
Package contents
1 × Lyophilized Powder (10mg) vial of MOTS-C, batch-matched Certificate of Analysis, and handling documentation.
Documented research applications
- Insulin sensitivity and Type 2 diabetes research
- Exercise mimetic and metabolic studies
- Mitochondrial biogenesis research
- Longevity and aging research
- AMPK pathway pharmacology
MOTS-C lab testing
HPLC purity result
99.45%
Lot / batch
AFL-MOTSC-2026-814
Test date
2026-03-06
Testing method
Reversed-phase HPLC with mass-spectrometry identity confirmation
Every lot of MOTS-c we list is supplied with a lot-matched Certificate of Analysis. Identity is confirmed by mass spectrometry and purity is measured by reversed-phase HPLC, with both results reported for the specific lot printed on the vial label. The certificate travels with the order, so the documentation can be reconciled against the material on receipt. Purity is a lot-specific value: read the figure on the certificate that matches your vial rather than treating it as a fixed product attribute. Supplied for laboratory research use only.
MOTS-C shipping and support
Orders placed before 2:00 PM ET ship the same business day from our USA facility. Standard delivery lands in 2–4 business days; expedited and priority options are available at checkout. Every order over $300 ships free. If anything arrives damaged or off-spec we replace it — no restocking fees, no upsell. Customer support is human-staffed and replies to research and order emails in under one hour during business days.
MOTS-C FAQ
What is MOTS-C studied for?
MOTS-C appears in laboratory research covering longevity research, diabetes studies, exercise physiology. Every reference describes in-vitro or preclinical study models, not outcomes in people.
Does MOTS-C include a Certificate of Analysis?
Yes. Each MOTS-C lot ships with a batch-specific third-party Certificate of Analysis reporting 99.4% purity by reversed-phase HPLC with mass-spectrometry identity confirmation. The COA linked on this page matches the lot number printed on the vial.
What form does MOTS-C arrive in and how is it stored?
MOTS-C is supplied as lyophilized powder in a sealed vial with its lot documentation. Store at -20°C (Freezer), protect the vial from light and avoid repeated freeze–thaw cycles.
Does HPLC purity tell me the net peptide content?
No. HPLC area-percent purity and net peptide content are different measurements. Review the report for each value rather than treating them as interchangeable. Read about peptide purity versus net content.
How much does MOTS-c cost?
MOTS-C is listed in these sizes: 10mg at $60.00 per vial ($6.00 per mg); 40mg at $140.00 per vial ($3.50 per mg). Check the strength selector for availability and the linked Certificate of Analysis for the selected material. Shipping is shown at checkout.
Where can I buy MOTS-c in the USA?
Amino Fuel Labs ships 99.4% HPLC-verified MOTS-c same-day from a USA facility, with a batch-specific third-party Certificate of Analysis in every box and free shipping over $300.
What is MOTS-c researched for?
MOTS-c is a mitochondrial-derived peptide studied for AMPK activation, insulin sensitivity, exercise-mimetic effects, and longevity pathways — a 2024 iScience study confirmed it directly binds casein kinase 2 to modulate skeletal-muscle function.
What purity is your MOTS-c for sale?
Every batch of MOTS-c for sale at Amino Fuel Labs is independently HPLC-verified at 99.4% purity with mass-spectrometry identity confirmation by an independent third-party lab. The current batch-specific COA is published at /coa/11 and ships with every order.
What size is the MOTS-c vial?
Our standard MOTS-c for sale is a single 10 mg lyophilized vial priced at $65.
How fast does MOTS-c ship?
All MOTS-c orders ship same-day from our USA fulfillment center on orders placed before 2:00 PM ET, Monday through Friday. Standard delivery is 2–4 business days.
Why is MOTS-C called an exercise mimetic?
MOTS-C activates AMPK and increases mitochondrial biogenesis — the same molecular pathways triggered by aerobic exercise. Preclinical models show similar improvements in glucose disposal and endurance.
Is MOTS-C 10mg or 40mg better for research?
The 10mg vial is the standard research size. The 40mg vial is bulk pricing for longer protocols — same compound, same purity, lower cost per mg.
What does the COA cover?
≥99.4% HPLC purity, mass-spec sequence confirmation, endotoxin testing and lot-specific batch number.
Research Use Only. This product is intended strictly for laboratory research purposes. It is not intended for consumption, diagnosis, treatment, prevention or clinical application.
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Order MOTS-C
MOTS-C · $60.00
Research Use Only. This product is intended strictly for laboratory research purposes. It is not intended for consumption, diagnosis, treatment, prevention or clinical application.
Research Use Only. This product is intended strictly for laboratory research purposes. It is not intended for consumption, diagnosis, treatment, prevention or clinical application. Read the full disclaimer.
